Why Don’t All Whales Have Cancer?

blue2g.gif

Knowing my fascination with body size variation among organisms , Peter sent a link along for a new paper, “Why don’t all whales have cancer? A novel hypothesis resolving Peto’s paradox.” Included in the email was a gentle prodding to post on this unique paper.

143_1S.jpgPeto’s paradox is that cancer is fundamentally different across mammals. If all mammalian cells have an equal probability of developing a mutation leading to cancer, all else being equal, then larger sized organisms with more cells should have a higher incidence of cancer. Equally, because larger organisms are longer lived then the probability also increases for any one cell to develop a, onogenic mutation. However, published literature reviews find no correlation between cancer incidence and body size.

This relationship should be easily seen given the tremendous size range of mammals from the bumblebee bat at mere 2g to a blue whale at 190,000 kg. For example, cancer among wild animals (<5%) is typically far below the percentage for humans (20-30%) irrespective of body size. Percentages in wild animals can approach 80% as in the Tasmanian devil or woodchucks but have very specific causes. In the later case of woodchucks, cancer is connected to a hepatitis virus. For cetaceans, and especially baleen whales, both large and long lived, we expect the incidence of cancer to be high. Cancer rates are high in belugas in the St. Lawrence estuary but related to agricultural and industrial pollution. However, belugas represent a rare case in cetaceans, with one study documenting only 33 cases before 2002. So what accounts for this paradox? One potential reason is that we have undersampled individuals with cancer. This is not likely if we assume that all mammalian cells, despite the organism, are likely to become cancerous. If we assume a reasonable 2% carcinogenic risk and just account for differences in size and not lifespan, then conservatively a whale has

0.00000000000000000000000000000000000000000000000000227

chance of having a cancer free life. If poachers didn’t kill them first, 96% of elephants would also have cancer.

So what accounts for Peto’s paradox?


whalecancer.jpg
Cheater tumor cells. When oxygen is insufficient in a tumor, cells secrete tumor angiogenic factors (TAF) that promote vascularization of the tumor. Some cells “cheat the system” failing to secrete TAF and parasitize the existing vascular network thus inhibiting growth. These tumor are called hypertumors and eventually become inviable. What is needed for a hypertumor to develop is time, which larger organisms have. In a large organism like a blue whale, a tumor can reach substantial size before disrupting processes and becoming lethal which affords more time. However, in the bumblebee bat, tumor can reach a lethal size quickly before a hypertumor can develop. The authors develop a simulation to test these ideas demonstrating the percentage of fatalities actually decreases with increasing body size (above figure 3).

And no this doesn’t provide justification for you cramming your pie-hole with more…um…pie.

Dr. M (1801 Posts)

Craig McClain is the Executive Director of the Lousiana University Marine Consortium. He has conducted deep-sea research for 20 years and published over 50 papers in the area. He has participated in and led dozens of oceanographic expeditions taken him to the Antarctic and the most remote regions of the Pacific and Atlantic. Craig’s research focuses on how energy drives the biology of marine invertebrates from individuals to ecosystems, specifically, seeking to uncover how organisms are adapted to different levels of carbon availability, i.e. food, and how this determines the kinds and number of species in different parts of the oceans. Additionally, Craig is obsessed with the size of things. Sometimes this translated into actually scientific research. Craig’s research has been featured on National Public Radio, Discovery Channel, Fox News, National Geographic and ABC News. In addition to his scientific research, Craig also advocates the need for scientists to connect with the public and is the founder and chief editor of the acclaimed Deep-Sea News (http://deepseanews.com/), a popular ocean-themed blog that has won numerous awards. His writing has been featured in Cosmos, Science Illustrated, American Scientist, Wired, Mental Floss, and the Open Lab: The Best Science Writing on the Web.