In the evolution of fishes, this is a one seahorse race*

Hippocampus hystrix (Spiny seahorse)

*alternative titles include “Looking a gift seahorse (genome) in the mouth”, “My kingdom for a seahorse genome”, “Hold your seahorses“, and “The galloping evolution of seahorses“.

Let’s face it, seahorses, pipefishes, and seadragons are messed up. That’s not a subjective opinion but an evolutionary fact.  It’s like all the approximately 300 species in Syngnathidae (the family of fish that contains all these critters) held a meeting and decided unanimously “Nah, screw it, we’ll do things however we damn well please.”  The Syngnathids are revolutionaries of the fish world.  ¡Viva la Evolución Revolución!

Seriously, almost everything in these species is different.  There is the elongated snouts and small mouths and jaws.  The pelvic and caudal fins are often gone.  The scales are replaced with an armor of bony plates.  Let’s not forget about the whole “male pregnancy” thing where the males nourish the developing embryos in a pouch.  Seahorses take it all to a whole other level with the prehensile tail and the vertical body axis.

So ultimately, one is left wondering what’s up with those genes?  Well, thanks to an intrepid group of geneticist, the complete genome of the tiger tail seahorse, Hippocampus comes, is complete.  With the full genome comes great power, the ability to compare this genome to the other sequenced fish.

Part of the story regarding the bizarreness of seahorses is gene loss.   Secretory calcium-binding phosphoprotein (SCPP) genes code for matrix proteins that are important in the formation of bone and teeth.  These genes are completely missing in Hippocampus comes and may explain why seahorses do not have teeth.  Did I forget to mention that?  Yeah seahorses and seadragons are toothless. The tbx4 gene, conserved in jawed vertebrates, acts as a regulator of hindlimb formation.  The gene is completely absent in the seahorse genome and explains the absence of those pesky pelvic fins.

What about that whole “male pregnancy” thing?   The H. comes genome contains six pastn genes, part of a family of genes that regulate the hatching of embryos.  The researchers conducted extra work, like the genome was not enough, suggesting a role for these pastn genes in brood pouch development and/or hatching of embryos within the brood pouch prior to birth.

Seahorses have also apparently lost many conserved noncoding genes (CNEs) that function as enhancers, repressors, and insulators of other genes.  1,612 CNEs have been lost in seahorses.  Compare this to the 281 in the Nile perch.  It is unclear how the loss of the CNEs may be related to some of the oddities of the seahorse, but loss of CNEs is tied to moderate short stature and shortened limbs in humans.

How I imagine the scientists of the study acted once they finished the genome

The awesomeness of this kind of work cannot even be articulated.  The researchers have done an amazing job of unpacking the genome of a seahorse and showing how genome evolution directly leads to all the uniqueness of seahorses.  Admittedly, I am little disappointed in not seeing a discussion of the prehensile tails genes and armored plating discussed. I guess I’ll need to wait a bit to build my army of aquatic minions to take over the world.

Dr. M (1759 Posts)

Craig McClain is the Executive Director of the Lousiana University Marine Consortium. He has conducted deep-sea research for 20 years and published over 50 papers in the area. He has participated in and led dozens of oceanographic expeditions taken him to the Antarctic and the most remote regions of the Pacific and Atlantic. Craig’s research focuses on how energy drives the biology of marine invertebrates from individuals to ecosystems, specifically, seeking to uncover how organisms are adapted to different levels of carbon availability, i.e. food, and how this determines the kinds and number of species in different parts of the oceans. Additionally, Craig is obsessed with the size of things. Sometimes this translated into actually scientific research. Craig’s research has been featured on National Public Radio, Discovery Channel, Fox News, National Geographic and ABC News. In addition to his scientific research, Craig also advocates the need for scientists to connect with the public and is the founder and chief editor of the acclaimed Deep-Sea News (http://deepseanews.com/), a popular ocean-themed blog that has won numerous awards. His writing has been featured in Cosmos, Science Illustrated, American Scientist, Wired, Mental Floss, and the Open Lab: The Best Science Writing on the Web.


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